Electronic address: 10 Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy. Electronic address: 9 Vascular Surgery, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Electronic address: 8 Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy Center for Atherosclerosis, Department of Medicine, Policlinico Tor Vergata, 00133 Rome, Italy. Electronic address: 7 Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy. Electronic address: 6 Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy Center for Atherosclerosis, Department of Medicine, Policlinico Tor Vergata, 00133 Rome, Italy. Electronic address: 5 Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy. Electronic address: 4 Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy Center for Atherosclerosis, Department of Medicine, Policlinico Tor Vergata, 00133 Rome, Italy. Electronic address: 3 Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy. Electronic address: 2 Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy OrchideaLab S.r.l., Via del Grecale 6, Morlupo, Rome, Italy IRCCS San Raffaele Pisana, 00166 Rome, Italy. Electronic address: 1 Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy. 1 Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.neoformans, thus representing a vehicle of chronic intracellular infection. Our study suggests that, in idiopathic CD4? lymphocytopenia, macrophages can efficiently phagocytize but inefficiently digest C. Electron microscopy demonstrated that inflammation was caused by Cryptococcus neoformans, which was localized exclusively within macrophages, where it grew with budding. At autopsy, inflammatory cells, CD8+ lymphocytes and abundant macrophages but not CD4+ lymphocytes were infiltrating the meninges at the base of the brain. Cerebrospinal fluid showed mild pleocytosis, but the etiology was not revealed by extensive analysis.
neoformans, thus representing a vehicle of chronic intracellular infection.ĪB - A 64-year-old man with idiopathic CD4+ lymphocytopenia developed cognitive impairment and gait ataxia with isolated obstructive hydrocephalus, which was fatal.
N2 - A 64-year-old man with idiopathic CD4+ lymphocytopenia developed cognitive impairment and gait ataxia with isolated obstructive hydrocephalus, which was fatal. T1 - Difficulty diagnosing chronic cryptococcal meningitis in idiopathic CD4+ lymphocytopenia
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